Bio Break: Real-Time Imaging for Targeted Drug Delivery

In this episode of Bio Break, Nick and Joris discuss the fascinating world of real-time imaging for targeted drug delivery. When delivering drugs to precise locations in the body, how do we ensure they reach the right spot? The answer lies in medical imaging technologies such as MRI, CT, and ultrasound, which play a crucial role in guiding complex drug delivery devices.

Nick starts by asking how imaging technologies help visualize drug targeting during delivery. Joris explains that MRI (Magnetic Resonance Imaging), CT (Computed Tomography), and ultrasound are the three most commonly used imaging techniques. Each has its advantages and limitations depending on the application.

MRI offers exceptional resolution and is ideal for deep-tissue targeting, such as brain delivery for conditions like Parkinson’s disease. However, intraoperative MRI machines are less accessible in hospitals, making their real-time use challenging.
CT scanning is more widely available and excellent for bone-related targeting, such as spinal drug delivery. While it has slightly lower resolution than MRI, it is a practical and widely adopted solution in medical settings.
Ultrasound is the most real-time imaging method and is commonly used for nerve blocks and pain management. However, it has depth limitations and is ineffective for regions behind bone, such as the brain.

Nick and Joris also discuss the future of medical imaging in drug delivery. With advancements in 3D imaging and computational modeling, physicians will soon have better spatial awareness of the drug delivery process, improving precision and patient outcomes.

As medical imaging evolves, AI-driven technologies and 3D imaging integration will revolutionize precision drug delivery, making it more efficient and accessible.

Real-Time Imaging for Targeted Drug Delivery

A laboratory or engineering workstation featuring a high-precision stereo microscope mounted on an articulated arm, positioned beside two computer monitors displaying 3D CAD models or imaging of a complex mechanical or biomedical device. The workspace also includes a keyboard, mouse, and a metallic container, all situated on a clean white desk in a dimly lit, modern lab environment.

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Three engineers are assembling or troubleshooting a large industrial or medical device prototype in a workshop. One person is seated in a wheelchair, another is standing behind the structure, and a third is kneeling on top of the machine for internal access. The workspace includes tools, laptops, electronic parts, and a large diagram of the device on the wall.

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A laptop on a wooden desk displays a digital document icon on its screen. Beside it, bold text reads "Design History Files Explained," highlighting the topic of regulatory documentation in medical device development.

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Two colorful paper boats—one red and one yellow—float on a blue background with illustrated white waves beneath them. Bold text reads "From Idea to Impact," symbolizing innovation and progress in medical device development.