Ingestible Capsules: Future of GI Diagnostics and Drug Delivery

Ariana Wilson and Mark Drlik seated against a white background, wearing lavalier microphones. The woman on the left has long brown curly hair and is wearing a beige cardigan over a taupe top. The man on the right is wearing glasses and a blue button-up shirt. They appear to be engaged in conversation or a video interview.
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Ingestible Capsules: Future of GI Diagnostics and Drug Delivery

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In this episode of MedDevice by Design, Mark Drlik and Ariana Wilson introduce the fascinating world of ingestible capsules—tiny, swallowable medical devices that are revolutionizing gastrointestinal health monitoring and targeted therapy.

What Are Ingestible Capsules?

Ingestible capsules are advanced devices designed to be swallowed and travel through the gastrointestinal tract. Originally developed for imaging purposes, they have evolved to support functions like microbiome sampling, localized drug delivery, and even systemic therapies.

The early pioneers, like Given Imaging, brought capsule endoscopy into clinical use. More than a million people have used these capsules to detect bleeding or abnormalities in the stomach and intestines. Today, innovations allow some capsules to autonomously identify their location using onboard sensors and light reflection, removing the need for external imaging like CT or ultrasound.

Key Innovations and Use Cases

Mark explains how newer capsules can:

  • Autonomously identify their position in the GI tract
  • Collect biological samples from specific regions
  • Deliver drugs to targeted locations
  • Break through intestinal walls to deliver systemic treatments

This growing technology is gaining traction for its ability to interact with the complex and previously hard-to-reach environment of the gut.

Development Challenges

Packing motors, batteries, and sensors into a capsule measuring just 11.6 mm by 26 mm is no small feat. Mark compares its computing power to his old Nintendo, showcasing how much performance engineers now fit into a swallowable form factor.

Looking Ahead

The future of ingestible capsules includes more accurate positioning systems, longer battery life, and expanded use in diagnostics, treatment, and monitoring. This episode highlights the ingenuity behind these devices and the opportunities they offer in transforming patient care.

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